abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease. ALS selectively causes degeneration in upper and lower (spinal) motor neurons, leading to muscle weakness, paralysis and death by ventilatory failure. Although ventilatory failure is generally the cause of death in ALS, little is kn...

journal_title：Respiratory physiology & neurobiology

authors： Nichols NL,Van Dyke J,Nashold L,Satriotomo I,Suzuki M,Mitchell GS

更新日期：2013-11-01 00:00:00

abstract：:Breathing disturbances are a major challenge in Rett Syndrome (RTT). These disturbances are more pronounced during wakefulness; but irregular breathing occurs also during sleep. During the day patients can exhibit alternating bouts of hypoventilation and irregular hyperventilation. But there is significant individual ...

journal_title：Respiratory physiology & neurobiology

authors： Ramirez JM,Ward CS,Neul JL

更新日期：2013-11-01 00:00:00

abstract：:Obesity is a national health issue in the US. Among the many physiological changes induced by obesity, it also presents a unique challenge to ventilatory control during exercise due to increased metabolic demand of moving larger limbs, increased work of breathing due to extra weight on the chest wall, and changes in b...

journal_title：Respiratory physiology & neurobiology

authors： Babb TG

更新日期：2013-11-01 00:00:00

abstract：:Haematological responses throughout 4 w of initial acclimation (IA) and three paradigms of re-acclimation (RA) to hypoxia (FI(O₂)) were examined in female mice. We hypothesised that (i) haematological responses would be increased during re-exposure, resulting in greater O₂-carrying capacity in RA compared to IA; and (...

journal_title：Respiratory physiology & neurobiology

authors： MacNutt MJ,Rupert JL,Sheel AW

更新日期：2013-10-01 00:00:00

abstract：:We investigated the signal transmission pathway by which activation of μ-opioid receptors attenuates acetylcholine (ACh) release in bovine trachealis. Electrical stimulation (ES)-induced [(3)H]-ACh release was determined in bovine tracheal smooth muscle strips pre-incubated with either the Gi-protein inhibitor pertuss...

journal_title：Respiratory physiology & neurobiology

authors： Baroffio M,Brichetto L,Franco L,Crimi E,Rehder K,Brusasco V

更新日期：2013-10-01 00:00:00

abstract：:Allergen instillation in anaesthetized vs. awake animals results in increased distribution of allergen in the lung. Halothane is a more potent bronchodilator of the small airways than isoflurane. As small airways contribute to asthma pathogenesis, we questioned whether intranasal challenge under halothane vs. isoflura...

journal_title：Respiratory physiology & neurobiology

authors： Borges MC,Marchica CL,Narayanan V,Ludwig MS

更新日期：2013-10-01 00:00:00

abstract：:To assess the occurrence of tidal expiratory flow limitation (EFL) and/or dynamic pulmonary hyperinflation (DH) in chronic heart failure (CHF) during exercise 15 patients with stable systolic CHF, aged 69 ± 6yr, underwent pulmonary function testing and incremental cardio-pulmonary exercise testing. They subsequently p...

journal_title：Respiratory physiology & neurobiology

authors： Chiari S,Torregiani C,Boni E,Bassini S,Vizzardi E,Tantucci C

更新日期：2013-10-01 00:00:00

abstract：:Bronchospasm may be part of the response to systemic anaphylaxis in humans. The anaphylactic shock has been characterized in allergic rats, but little data are available on the concurrent changes in airway-lung mechanics. The aim was to describe the respiratory resistance (Rrs) and reactance (Xrs) response to ovalbumi...

journal_title：Respiratory physiology & neurobiology

authors： Barthel G,Zheng F,Demoulin B,Davidson J,Montémont C,Gaburro J,Mertes PM,Marchal F

更新日期：2013-10-01 00:00:00

abstract：:This review examines the role that respiratory plasticity has in the maintenance of breathing stability during sleep in individuals with sleep apnea. The initial portion of the review considers the manner in which repetitive breathing events may be initiated in individuals with sleep apnea. Thereafter, the role that t...

journal_title：Respiratory physiology & neurobiology

authors： Mateika JH,Syed Z

更新日期：2013-09-15 00:00:00

abstract：:Sleep-disordered breathing is accompanied by neural injury that affects a wide range of physiological systems which include processes for sensing chemoreception and airflow, driving respiratory musculature, timing circuitry for coordination of breathing patterning, and integration of blood pressure mechanisms with res...

journal_title：Respiratory physiology & neurobiology

authors： Harper RM,Kumar R,Ogren JA,Macey PM

更新日期：2013-09-15 00:00:00

abstract：:Serotonin (5-HT), norepinephrine and orexins (ORX) are the three best established mediators of wake-related activation of hypoglossal (XII) motoneurons that innervate the muscles of the tongue. Since the tongue's use is temporarily closely aligned with the rest-activity cycle, we tested whether expression of mRNA for ...

journal_title：Respiratory physiology & neurobiology

authors： Volgin DV,Stettner GM,Kubin L

更新日期：2013-09-15 00:00:00

abstract：:In obstructive sleep apnea (OSA) patients, inspiratory activation (IA) of lingual muscles protects the upper airway from collapse. We aimed to determine when rats' lingual muscles exhibit IA. In 5 Sprague-Dawley and 3 Wistar rats, we monitored cortical EEG and lingual, diaphragmatic and nuchal electromyograms (EMGs), ...

journal_title：Respiratory physiology & neurobiology

authors： Stettner GM,Rukhadze I,Mann GL,Lei Y,Kubin L

更新日期：2013-09-15 00:00:00

abstract：:Chronic mountain sickness (CMS) or lack of adaptation to live in high altitudes is related to environmental hypoxia and excessive erythrocytosis (EE) (hemoglobin >21 and >19 g/dL for men and women, respectively). Diagnosis of CMS ("Qinghai CMS Score") is based on seven signs/symptoms (breathlessness and/or palpitation...

journal_title：Respiratory physiology & neurobiology

authors： Gonzales GF,Rubio J,Gasco M

更新日期：2013-08-15 00:00:00

abstract：:It has been shown that tiny gas nanobubbles form spontaneously on a smooth hydrophobic surface submerged in water. These nanobubbles were shown to be the source of gas micronuclei from which bubbles evolved during decompression of silicon wafers. We suggest that the hydrophobic inner surface of blood vessels may be a ...

journal_title：Respiratory physiology & neurobiology

authors： Arieli R,Marmur A

更新日期：2013-08-01 00:00:00

abstract：:Lung ultrasonography (LUS) and computed tomography (CT) were compared for quantitative assessment of extravascular lung water (EVLW) in 10 isolated bovine lung lobes. LUS and CT were obtained at different inflation pressures before and after instillation with known amounts of hypotonic saline. A video-based quantitati...

journal_title：Respiratory physiology & neurobiology

authors： Corradi F,Ball L,Brusasco C,Riccio AM,Baroffio M,Bovio G,Pelosi P,Brusasco V

更新日期：2013-07-01 00:00:00

abstract：:Evidence is available about the role of inflammatory/immunological factors in the physiology and plasticity of the carotid body, with potential clinical implications in obstructive sleep apnea syndrome and sudden infant death syndrome. In humans, lymphomonocytic aggregations (chronic carotid glomitis) have been report...

journal_title：Respiratory physiology & neurobiology

authors： Porzionato A,Macchi V,De Caro R,Di Giulio C

更新日期：2013-06-01 00:00:00

abstract：:The resurgence of pertussis has been the subject of considerable debate. Hypotheses to explain increased reporting in developed countries have focused mainly on three aspects: (1) increased recognition of the disease in adolescents and adults; (2) waning of vaccine-induced immunity and (3) loss of vaccine efficacy due...

journal_title：Respiratory physiology & neurobiology

authors： Nitsch-Osuch A,Korzeniewski K,Kuchar E,Zielonka T,Życińska K,Wardyn K

更新日期：2013-06-01 00:00:00

abstract：:Hypertrophy of lymphoid tissue within the throat in children leads to a number of respiratory problems and sleep disorders. The aim of this study was to evaluate the prevalence of the above-mentioned changes depending on the location of overgrown lymphoid tissue, BMI, and coexisting allergies. The study was based on a...

journal_title：Respiratory physiology & neurobiology

authors： Dzięciołowska-Baran E,Dąbrowski P,Gawlikowska-Sroka A,Poziomkowska-Gęsicka I,Baran S

更新日期：2013-06-01 00:00:00

abstract：:Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high altitude (>2500m) resulting in marked arterial hypoxemia and polycythemia. This case-control study explores the possibility that sleep-disordered breathing (SDB) and associated oxidative stress contribute to the etiology ...

journal_title：Respiratory physiology & neurobiology

authors： Julian CG,Vargas E,Gonzales M,Dávila RD,Ladenburger A,Reardon L,Schoo C,Powers RW,Lee-Chiong T,Moore LG

更新日期：2013-04-01 00:00:00

abstract：:High frequency spinal cord stimulation (HF-SCS) is a method of inspiratory muscle activation resulting in phrenic motoneuron activation via stimulation of spinal cord pathways. The specific pathways mediating this response, however, are unknown. The aim of this study was to assess the potential role of upper cervical ...

journal_title：Respiratory physiology & neurobiology

authors： Dimarco AF,Kowalski KE

更新日期：2013-03-01 00:00:00

abstract：:Evidence from liquid-filled rat lungs supported the presence of CO2-dependent, active relaxation of parenchyma under normoxia by unknown mechanisms (Emery et al., 2007). This response may improve matching of alveolar ventilation (V˙A) to perfusion (Q˙) by increasing compliance and V˙A in overperfused (high CO2) region...

journal_title：Respiratory physiology & neurobiology

authors： Emery MJ,Eveland RL,Min JH,Hildebrandt J,Swenson ER

更新日期：2013-03-01 00:00:00

abstract：:We hypothesize that isoflurane and ketamine impact ventilatory pattern variability (VPV) differently. Adult Sprague-Dawley rats were recorded in a whole-body plethysmograph before, during and after deep anesthesia. VPV was quantified from 60-s epochs using a complementary set of analytic techniques that included const...

journal_title：Respiratory physiology & neurobiology

authors： Chung A,Fishman M,Dasenbrook EC,Loparo KA,Dick TE,Jacono FJ

更新日期：2013-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and erythropoietin (EPO) exert neurotrophic and neuroprotective effects in the CNS. We recently demonstrated that VEGF, EPO and their receptors (VEGF-R2, EPO-R) are expressed in phrenic motor neurons, and that cervical spinal VEGF-R2 and EPO-R activation elicit long-lasting ph...

journal_title：Respiratory physiology & neurobiology

authors： Dale EA,Mitchell GS

更新日期：2013-02-01 00:00:00

abstract：:The aim of this study was to compare the ventilatory responses of C57BL6 female and male mice during a 15 min exposure to a hypoxic-hypercapnic (H-H) or a hypoxic (10% O(2), 90% N(2)) challenge and subsequent return to room air. The ventilatory responses to H-H were similar in males and females whereas there were pron...

journal_title：Respiratory physiology & neurobiology

authors： Palmer LA,May WJ,deRonde K,Brown-Steinke K,Gaston B,Lewis SJ

更新日期：2013-02-01 00:00:00

abstract：:The purpose of this study was to compare simultaneous measurements of tidal volume (Vt) by optoelectronic plethysmography (OEP) and spirometry during a maximal cycling exercise test to quantify possible differences between methods. Vt measured simultaneously by OEP and spirometry was collected during a maximal exercis...

journal_title：Respiratory physiology & neurobiology

authors： Layton AM,Moran SL,Garber CE,Armstrong HF,Basner RC,Thomashow BM,Bartels MN

更新日期：2013-01-15 00:00:00

abstract：:Inorganic nitrate has been shown to reduce oxygen cost during exercise. Since the nitrate-nitrite-NO pathway is facilitated during hypoxia, we investigated the effects of dietary nitrate on oxygen consumption and cardiovascular responses during apnea. These variables were measured in two randomized, double-blind, plac...

journal_title：Respiratory physiology & neurobiology

authors： Schiffer TA,Larsen FJ,Lundberg JO,Weitzberg E,Lindholm P

更新日期：2013-01-15 00:00:00

abstract：:In day 15 chicken embryos, we determined the time course responses of acid-base balance and hematological respiratory variables during 24h exposure to 15, 20, 40 or 90% O(2), in the presence of 5% CO(2). Hypercapnic respiratory acidosis was initially (2h) only slightly (∼20%) compensated by metabolic alkalosis in norm...

journal_title：Respiratory physiology & neurobiology

authors： Mueller CA,Tazawa H,Burggren WW

更新日期：2013-01-15 00:00:00

abstract：:With hypoxic exposure ventilation is elevated through the hypoxic ventilatory response. We tested the hypothesis that the resulting hypocapnia reduces maximal exercise capacity by decreasing (i) cerebral blood flow and oxygenation and (ii) the ventilatory drive. Eight subjects performed two incremental exercise tests ...

journal_title：Respiratory physiology & neurobiology

authors： Siebenmann C,Sørensen H,Jacobs RA,Haider T,Rasmussen P,Lundby C

更新日期：2013-01-15 00:00:00

abstract：:Recently, we reported that dyspnea on exertion is strongly associated with an increased oxygen cost of breathing in otherwise healthy obese women; the mechanism of dyspnea on exertion in obese men is unknown. Obese men underwent measurements of body composition, fat distribution, pulmonary function, steady state and m...

journal_title：Respiratory physiology & neurobiology

authors： Bernhardt V,Wood HE,Moran RB,Babb TG

更新日期：2013-01-15 00:00:00

abstract：:Previous studies have demonstrated that carbonic anhydrase inhibition with acetazolamide reduces exercise capacity. The mechanism responsible for this early fatigue is unclear, but may be partly mediated by impaired respiratory muscle function. Inspiratory muscle strength and endurance were assessed in seven healthy m...

journal_title：Respiratory physiology & neurobiology

authors： Gonzales JU,Scheuermann BW

更新日期：2013-01-15 00:00:00

abstract：:Not long ago, urea was believed to freely diffuse across plasma membranes. The discovery of specialized proteins to facilitate the movement of urea across the fish gill, similar to those found in mammalian kidney, was exciting, and at the same time, perplexing; especially considering the fact that, aside from elasmobr...

journal_title：Respiratory physiology & neurobiology

authors： McDonald MD,Gilmour KM,Walsh PJ

更新日期：2012-12-01 00:00:00

abstract：:Carotid bodies are sensory organs for monitoring arterial blood oxygen (O(2)) levels, and the ensuing reflexes maintain cardio-respiratory homeostasis during hypoxia. This article provides a brief update of the role of carbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body. Glomus cel...

journal_title：Respiratory physiology & neurobiology

authors： Prabhakar NR

更新日期：2012-11-15 00:00:00

abstract：:Rapid shallow breathing (RSB) is mainly mediated by bronchopulmonary C-fibers (PCFs). We asked whether this RSB could be modulated by opioids. In anesthetized rats right atrial bolus injection of phenylbiguanide (PBG) to evoke RSB was repeated after: (1) intravenously giving fentanyl (μ-receptor agonist), DPDPE (δ-rec...

journal_title：Respiratory physiology & neurobiology

authors： Zhang Z,Zhang C,Zhou M,Xu F

更新日期：2012-09-30 00:00:00

abstract：:We evaluated, by CFD simulation, effects of accessory ostium (AO) on maxillary sinus ventilation. A three-dimensional nasal model was constructed from an adult CT scan with two left maxillary AOs (sinus I) and one right AO (sinus II), then compared to an identical control model with all AOs sealed (sinuses III and IV)...

journal_title：Respiratory physiology & neurobiology

authors： Zhu JH,Lee HP,Lim KM,Gordon BR,Wang de Y

更新日期：2012-08-15 00:00:00

abstract：:The mechanisms of cough in asthma are unclear. Asthma is associated with an oxidative stress. Many reactive oxygen species sensitize or activate sensory C-fibers which are capable to induce cough. It was hypothesized that oxidative stress in the airways might contribute to the cough severity in asthma. Exhaled breath ...

journal_title：Respiratory physiology & neurobiology

authors： Koskela HO,Purokivi MK,Nieminen RM,Moilanen E

更新日期：2012-05-31 00:00:00

abstract：:This study investigated the effects of four exposures to normobaric hypoxia (SIH group; FIO₂ = 0.120, N=10) or placebo-control normoxia (Control group; FIO₂ = 0.209, N=9) on cardio-respiratory responses to hypoxic exercise. Before and after the exposures all subjects performed a constant power test (CP) to exhaustion ...

journal_title：Respiratory physiology & neurobiology

authors： Debevec T,Mekjavic IB

更新日期：2012-04-30 00:00:00

abstract：:Hyperventilation is one way to cause activation on the electroencephalogram (EEG) to diagnose brain disorders. The hyperventilation is also known to affect on the delta power in EEG. This study divided the total delta wave into low, middle, and high bands corresponding to the wave frequency. The power in these three d...

journal_title：Respiratory physiology & neurobiology

authors： Kim YS,An SJ,Lee HJ,Choi HJ

更新日期：2012-04-30 00:00:00

abstract：:Angiotensin II (Ang II) has been demonstrated as a pro-inflammatory effect in acute lung injury, but studies of the effect of Ang II on the formation of pulmonary edema and alveolar filling remains unclear. Therefore, in this study the regulation of alveolar fluid clearance (AFC) and the expression of epithelial sodiu...

journal_title：Respiratory physiology & neurobiology

authors： Deng J,Wang DX,Deng W,Li CY,Tong J,Ma H

更新日期：2012-04-15 00:00:00

abstract：:A negative influence of central chemosensitivity on peripheral chemoreflex response has been demonstrated recently in a decerebrate-vagotomized rat preparation in situ with separate carotid body and brainstem perfusions. Here, we report similar negative influences of hypercapnia on the hypoxic respiratory response in ...

journal_title：Respiratory physiology & neurobiology

authors： Tin C,Song G,Poon CS

更新日期：2012-04-15 00:00:00

abstract：:Rapid intravenous saline infusion, a model meant to replicate the initial changes leading to pulmonary interstitial edema, increases pulmonary arterial pressure in humans. We hypothesized that this would alter lung perfusion distribution. Six healthy subjects (29 ± 6 years) underwent magnetic resonance imaging to quan...

journal_title：Respiratory physiology & neurobiology

authors： Henderson AC,Sá RC,Barash IA,Holverda S,Buxton RB,Hopkins SR,Prisk GK

更新日期：2012-03-15 00:00:00